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Biggest comebacks in tech: IBM
Once upon a time, IBM was computing. It was so dominant that Stanley Kubrick named his all-seeing, god-complex computer in 2001: A Space Oddyssey after the company (HAL is only IBM shifted one letter back).
Then its mainframes were eclipsed by Microsoft's desktop computers and the corporate structure turned "inbred and ingrown", according to its rescuer. Louis Gerstner became CEO in 1993, ditched desktop computers and OS/2 and hauled the company back together.
Since then, IBM has returned to become one of the biggest and most profitable players in business computing. In 1993 its stock dipped as low as $10.5, now it's over $200.